AustralieFrV1, Main, Exploration, bibRecord, 00BD06

Hybrid genotypes in the pathogenic yeast Cryptococcus neoformans

Identifieur interne : 00BD06 ( Main/Exploration ); précédent : 00BD05; suivant : 00BD07

Hybrid genotypes in the pathogenic yeast Cryptococcus neoformans

Auteurs : Teun Boekhout [Pays-Bas] ; Bart Theelen [Pays-Bas] ; Mara Diaz [États-Unis] ; Jack W. Fell [États-Unis] ; Wim C. J. Hop [Pays-Bas] ; Edwin C. A. Abeln [Pays-Bas] ; Francoise Dromer [France] ; Wieland Meyer [Australie]

Source :

Microbiology : (Reading) [ 1350-0872 ] ; 2001.

RBID : Pascal:01-0338925

Descripteurs français

Pascal (Inist)
- Cryptococcus neoformans, Variation géographique, Sérotype, Variabilité génétique, Génotype, Hybride, Epidémiologie moléculaire, AFLP.

English descriptors

KwdEn :
- Amplified fragment length polymorphism, Cryptococcus neoformans, Genetic variability, Genotype, Geographical variation, Hybrid, Molecular epidemiology, Serotype.

Abstract

Amplified fragment length polymorphism (AFLP) genotyping of isolates of the pathogenic fungus Cryptococcus neoformans suggested a considerable genetic divergence between the varieties C. neoformans var. neoformans and C. neoformans var. grubii on the one hand versus C. neoformans var. gattii on the other. This divergence is supported by additional phenotypic, biochemical, clinical and molecular differences. Therefore, the authors propose the existence of two species, C. neoformans (Sanfelice) Vuillemin and C. bacillisporus Kwon-Chung, which differ in geographical distribution, serotypes and ecological origin. Within each species three AFLP genotypes occur, which differ in geographical distribution and serotypes. Differences in ecological origin (AIDS patients, non-AIDS patients, animals or the environment) were found to be statistically not significant. In C. neoformans as well as in C. bacillisporus one of the genotypes represented a hybrid. The occurrence of hybridization has consequences for the reproductive biology of the species, as new genotypes with altered virulence or susceptibility to antifungal drugs may arise through the exchange of genetic material.

Affiliations:

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Le document en format XML

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<series><title level="j" type="main">Microbiology : (Reading)</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amplified fragment length polymorphism</term>
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<term>Genetic variability</term>
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<term>Geographical variation</term>
<term>Hybrid</term>
<term>Molecular epidemiology</term>
<term>Serotype</term>
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<term>Variation géographique</term>
<term>Sérotype</term>
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<front><div type="abstract" xml:lang="en">Amplified fragment length polymorphism (AFLP) genotyping of isolates of the pathogenic fungus Cryptococcus neoformans suggested a considerable genetic divergence between the varieties C. neoformans var. neoformans and C. neoformans var. grubii on the one hand versus C. neoformans var. gattii on the other. This divergence is supported by additional phenotypic, biochemical, clinical and molecular differences. Therefore, the authors propose the existence of two species, C. neoformans (Sanfelice) Vuillemin and C. bacillisporus Kwon-Chung, which differ in geographical distribution, serotypes and ecological origin. Within each species three AFLP genotypes occur, which differ in geographical distribution and serotypes. Differences in ecological origin (AIDS patients, non-AIDS patients, animals or the environment) were found to be statistically not significant. In C. neoformans as well as in C. bacillisporus one of the genotypes represented a hybrid. The occurrence of hybridization has consequences for the reproductive biology of the species, as new genotypes with altered virulence or susceptibility to antifungal drugs may arise through the exchange of genetic material.</div>
</front>
</TEI>
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<name sortKey="Abeln, Edwin C A" sort="Abeln, Edwin C A" uniqKey="Abeln E" first="Edwin C. A." last="Abeln">Edwin C. A. Abeln</name>
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<country name="France"><region name="Île-de-France"><name sortKey="Dromer, Francoise" sort="Dromer, Francoise" uniqKey="Dromer F" first="Francoise" last="Dromer">Francoise Dromer</name>
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<country name="Australie"><noRegion><name sortKey="Meyer, Wieland" sort="Meyer, Wieland" uniqKey="Meyer W" first="Wieland" last="Meyer">Wieland Meyer</name>
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Hybrid genotypes in the pathogenic yeast Cryptococcus neoformans

Hybrid genotypes in the pathogenic yeast Cryptococcus neoformans

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri